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Albino Kalolo, MD, MSc, PhD


GHES LMIC Fellow 2019-2020

FELLOWSHIP SITE: Shinyanga Regional Hospital, Tanzania

Project Title: Cardiovascular risk factors, depression and quality of life in patients receiving antiretroviral therapy in rural Tanzania

Co-morbidities in people living with HIV infection have been widely reported. In particular, there is a growing burden of non-communicable diseases such as cardiovascular diseases, lipid disorders, diabetes mellitus, and metal health problems among people on highly active antiretroviral therapy (HAART). Existing studies barely report on the influence of each spectrum of diseases on patient progress and quality of life. This study aims to estimate the association between modifiable cardiovascular risk factors, depression and quality of life among patients receiving HAART in Tanzania.

Between August 2019 and July 2020, a cross-sectional study will be conducted among patients receiving HIV care and treatment in Shinyanga region. Validated tools will be used to gather background characteristics, cardiovascular risk factors, depression and quality of life from apparently healthy patients aged 18-60 years. The background assessment of each patient will include; socio-demographic characteristics, HAART use, (duration of use, first or second line and type of ARV drug) and patient progress (CD4 levels and Viral load).The cardiovascular risk assessment will be done using a cardiovascular risk assessment tool whereas depression will be assessed using a patient depression questionnaire (PHQ-9).The quality of life will be measured using the World Health organization quality of life (WHOQOL)-BREF measure. Records will be reviewed to supplement the data collected by questionnaire. Descriptive and inferential analyses (t-test, Mann-Whitney test and regression) will be used to understand the study population and relationship between variables respectively.

This study is set to contribute to the understanding of the influence of non-infectious chronic co-morbidities on patient progress and quality of life among patients on HAART in resource limited settings. The findings might contribute in designing programs to improve the quality of life of patients on HAART presenting with co-morbidities.