Ellise Gambahaya, MBChB, MMed

GHES LMIC Fellow 2016-2017

Home Institution: University of Zimbabwe
U.S. Institution: Stanford University

Project Title: Maternal and Infant outcomes of Peripartum Cardiomyopathy in a Zimbabwean Cohort

Peripartum cardiomyopathy is a rare condition occurs with a relatively high frequency in African women or those of African descent. Data from the Parirenyatwa echocardiography clinic showed that 28% of women of childbearing age with structural heart disease had a diagnosis of peripartum cardiomyopathy. The clinical outcome of women who develop this condition has been studied in a variety of settings including Zimbabwe. However there is paucity of data on the outcomes of infants born to mothers with peripartum cardiomyopathy particularly in relation to maternal outcomes. There is also limited data on the effect of breastfeeding practices on maternal treatment outcomes. The project seeks to determine the clinical outcomes of women who develop peripartum cardio myopathyand that of their infants within 6 months of diagnosis.

Main Objective:
To determine maternal and infant outcomes in patients with PPCM within six months of diagnosis.

Specific objectives:
1. To determine maternal outcomes within six months of diagnosis, namelya. The change in functional status of incident cases of peripartum cardiomyopathy 6 months after diagnosis.

b. To ascertain the rate of echocardiographic recovery of LV systolic function of patients with PPCM6 months after diagnosis (echocardiographic recovery being defined as an increase in the EF > 20%from baseline and complete recovery as EF>50%)

c. To determine the mortality rate of patients with PPCM up to 6 months after diagnosis

d. To determine the effect of breastfeeding practices of women with peripartum cardiomyopathy on their treatment outcomes.

2. To determine outcomes of infants born to mothers with peripartum cardiomyopathy, namelya. Infant health at birth as measured by; birthweight, APGAR score, gestational age in weeks andfetal death

b. Infant growth as measured by anthropometric measurements

c. Infant mortality