Komarla Lokesh, MBBS, DNB

lockeshGHES US Fellow 2014-2015

E-mail: kslokesh@gmail.com
Fellowship Site: JSS Medical College, Mysore, India
U.S. Institution: Florida International University

Project Title: Variation in prevalence of COPD in Mysore District: evaluation of oxidant stress, vitamin D levels and water contamination.

Chronic Obstructive Pulmonary Disease (COPD) is one of the major global health issues. It is one of the most common causes of disability and death that is still increasing and projected to be the 3rd most common cause of death by year 2020. There is wide variance in prevalence of COPD as demonstrated by different studies not only in different countries with varying genetic, environmental, nutritional, socio-cultural influences and tobacco consumption and exposure to biomass fuels, but also in regions close to each other with similar influences. The cause for these differences needs to be further evaluated with more focused research.

In an earlier survey done during 2007 to 2009 which includes 8400 subjects in 16 villages of Mysore and Nanjangud regions in Indian state of Karnataka, we observed a significant difference (1.69% in Mysore versus 21.64% in Nanjangud among males and 1.79% in Mysore versus 4.99% in Nanjangud among females) in the prevalence of chronic bronchitis between two geographically adjacent regions with similar background. There is a need to evaluate factors affecting this variance in genetically homogenous populations (Dravidian) living close to each other.

In this study, we aim to explore some of the possible risk factors in a sub-sample of these populations in Mysore and Nanjangud. The risk factors that will be assessed include nutritional inefficiencies by a dietary questionnaire and assessment for Vitamin D levels, oxidant stress and anti-oxidant reserves and water contamination with arsenic.