South Africa – Yale

Location
Tugela Ferry, KwaZuluNatal, South Africa

Site Institution
Philanjalo
KwaZuluNatal Department of Health
University of Kwazulu Natal

U.S. Institution
Yale Schools of Medicine and Public Health

U.S. Based Mentor

Gerald FriedlandGerald Friedland, MD
Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases)
E-mail: gerald.friedland@yale.edu

 

S_Shenoi_MG_5869 pref 1
Sheela Shenoi, MD, MPH
Assistant Professor of Medicine (AIDS); Assistant Professor
E-mail: sheela.shenoi@yale.edu

 

Local Mentor

 AnthonyMollAnthony Moll, MBChB
Senior Medical Officer at the Church of Scotland Hospital; Director of the HIV Clinic
E-mail: 4tonymoll@gmail.com

 

Research Focus
Community based strategies to confront epidemics of tuberculosis, HIV/AIDS and drug resistant tuberculosis

Site and Background
The training site is in Tugela Ferry, located in the Umzinyathi District of KwaZuluNatal, a traditional Zulu area and the third poorest district in South Africa. Philanjalo a local South African NGO founded by Dr. Tony Moll our host partner, in 1998 to address the rapidly growing epidemic of HIV/AIDS. Yale joined Philanjalo and the KZN Department of Health (DOH) and University of KwaZuluNatal in 2002 to strengthen and integrate HIV and TB care and treatment at this site. In 2005, we uncovered the third and disastrous epidemic of extensively drug resistant (XDR) TB. These convergent epidemics have been characterized by rapid and high mortality rates, overwhelmed TB and HIV care systems, ongoing health care and community transmission and epidemic propagation, all associated with extreme poverty, weak infrastructures, inadequate prevention strategies, late presentation to care, limited TB diagnostics and treatment options.

In response, we have worked collaboratively to characterize the convergent epidemics and have developed and implemented a comprehensive continuum of innovative integrated HIV and TB health care and community based strategies combined with operational research to strengthen clinical and public health programs, reduce the associated high rates of morbidity and mortality and decrease incidence and transmission of HIV and drug susceptible and drug resistant TB. We rapidly demonstrated acceptance, feasibility and utility and have successfully advocated for widespread scale up and dissemination. Current examples include the first national community based MDR TB treatment program and first integrated HIV and TB intensive case finding (ICF) program in rural South Africa. We are gratified now that we have preliminary evidence supporting the success of these efforts.

Current and Planned Projects include:
1) Expansion of community based integrated HIV and TB intensive case finding- Supported by CDC/PEPFAR, NIH K23 Award (Shenoi) KwaZuluNatal Department of Health, Gilead, Irene Diamond and Doris Duke Foundations (Friedland)
2) Development, implementation and evaluation of isoniazid prophylactic therapy for out of treatment HIV positive community members. Supported by CDC Implementation Science award (Moll, Shenoi)
3) Study of community based implementation of rapid point of care CD4 cell count (PIMA) technology, Supported by NIAID R21 grant (Friedland/Shenoi)
4) Mathematical Modeling to determine impact and cost effectiveness of community based strategies (PhD candidate Gilbert and School of Public Health Faculty)

Please visit:
http://tfcares.org
http://philanjalo.org.za
http://globalhealth.medicine.yale.edu/index.aspx
https://publichealth.yale.edu/research/training/ghes/South_Africa_HIV_TB.aspx