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Komarla Lokesh, MBBS, DNB

GHES LMIC Fellow 2014-2015

HOME INSTITUTION: JSS Medical College, Mysore, India
US Institution: Florida International University

Project Title: Prevalence and correlates of COPD and evaluation of predictors of progression in rural Nanjangud Taluk, Southern India.

Chronic Obstructive Pulmonary Disease (COPD) is a major global health issues. It is one of the most common causes of disability and death that is still increasing and projected to be the 3rd most common cause of death by year 2020. There is wide variance in prevalence of COPD as demonstrated by different studies not only in different countries with varying genetic, environmental, nutritional, socio-cultural influences and tobacco consumption and exposure to biomass fuels, but also in regions close to each other with similar influences. The cause for these differences needs to be further evaluated with more focused research.

This project is looking into levels of vitamin D and antioxidant reserves (using TBARS Thio-Barbituric Acid Reactive Substances and FRAP Ferric Reducing Antioxidant Power methods) in subjects with COPD and correlating it to markers of disease progression such as reductions in lung function (spirometry), exercise capacity (6 minute walk distance), increase in clinical symptoms such as cough, dyspnoea, anxiety and depression scores.