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Malinee Neelamegam, MBA, MPH, PhD

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GHES LMIC Fellow 2019-2020

FELLOWSHIP SITE: University of Malaya, Malaysia
U.S. INSTITUTION: Yale University

Project Title: Predictors of stroke, neuropsychological disorders and other geriatric syndromes among people with HIV in Malaysia

Treatment with antiretroviral therapy (ART) has increased life expectancy of people with HIV (PWH) in both high and low/middle income countries (LMIC). While ART has transformed HIV into a chronic, manageable condition, it presents with unique health issues due to its chronic disease nature, now with crucial implications on existing health systems in LMIC settings. PWH experience accelerated aging, with these consequences necessitating changes to HIV care delivery. Neurocognitive impairment and early aging in this vulnerable population puts them at a higher risk for impaired functional outcomes, multimorbidity and reduced quality of life.

Through a mixed-methods approach of the Malaysian HIV and Aging (MHIVA) study, we will examine the association between neuropsychological disorders, stroke and geriatric syndromes, and HIV. We will also determine the predictors of accelerated progression of these conditions in PWH and assess the perception about accentuated aging and HIV, and preference for aging/chronic diseases care in PWH.